Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule
نویسندگان
چکیده
منابع مشابه
The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.
A wide spectrum of birth defects is caused by deletions of the DiGeorge syndrome chromosomal region at 22q11. Characteristic features include cranio-facial, cardiac and thymic malformations, which are thought to arise form disturbances in the interactions between hindbrain neural crest cells and the endoderm of the pharyngeal pouches. Several genes have been identified in the shortest region of...
متن کاملHuman homologue of murine T200 glycoprotein
We report the identification of the human homologue of murine T200 glycoprotein. Peptide-mapping experiments suggest that the structure of the glycoprotein is highly conserved between the two species. Many of the properties of human T200 homologue are similar to those of murine T200 glycoprotein: it is broadly distributed within the hematopoietic system but is not detectable on nonhematopoietic...
متن کاملKidney injury molecule-1 expression in murine polycystic kidney disease.
Kidney injury molecule-1 (Kim-1) is a type 1 membrane protein maximally upregulated in proliferating and dedifferentiated tubular cells after renal ischemia. Because epithelial dedifferentiation, proliferation, and local ischemia may play a role in the pathophysiology of autosomal dominant polycystic kidney disease, we investigated Kim-1 expression in a mouse model of this disease. In the Pkd2(...
متن کاملAnterior-Posterior Patterning of the Avian Neuraxis
Nieuwkoop and Nigtevecht’s (1954) model of anterior-posterior patterning of the neuraxis states that the naive ectoderm first receives an ‘activation’ signal giving it an anterior, neural character and subsequently a ‘transformation’ signal that progressively caudalises the axis resulting in the full rostro-caudal pattern. Stern (2001) proposed a modification to this model that divides the firs...
متن کاملEndogenous Cerberus activity is required for anterior head specification in Xenopus.
We analyzed the endogenous requirement for Cerberus in Xenopus head development. 'Knockdown' of Cerberus function by antisense morpholino oligonucleotides did not impair head formation in the embryo. In contrast, targeted increase of BMP, Nodal and Wnt signaling in the anterior dorsal-endoderm (ADE) resulted in synergistic loss of anterior head structures, without affecting more posterior axial...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 1998
ISSN: 0012-1606
DOI: 10.1006/dbio.1997.8812